/* cifra - Clinical Trial Analysis System - Responsive CSS */

/* === Reset & Base === */
*, *::before, *::after { box-sizing: border-box; margin: 0; padding: 0; }

:root {
    --primary: #1a73e8;
    --primary-dark: #1557b0;
    --primary-light: #e8f0fe;
    --success: #0d9488;
    --warning: #f59e0b;
    --danger: #dc2626;
    --info: #2563eb;
    --gray-50: #f9fafb;
    --gray-100: #f3f4f6;
    --gray-200: #e5e7eb;
    --gray-300: #d1d5db;
    --gray-400: #9ca3af;
    --gray-500: #6b7280;
    --gray-600: #4b5563;
    --gray-700: #374151;
    --gray-800: #1f2937;
    --gray-900: #111827;
    --radius: 8px;
    --shadow: 0 1px 3px rgba(0,0,0,0.1), 0 1px 2px rgba(0,0,0,0.06);
    --shadow-md: 0 4px 6px rgba(0,0,0,0.1), 0 2px 4px rgba(0,0,0,0.06);
    --shadow-lg: 0 10px 15px rgba(0,0,0,0.1), 0 4px 6px rgba(0,0,0,0.05);
    --font-family: 'Yu Gothic', 'Hiragino Sans', 'Meiryo', sans-serif;
}

body {
    font-family: var(--font-family);
    font-size: 14px;
    line-height: 1.6;
    color: var(--gray-800);
    background: var(--gray-50);
    min-height: 100vh;
    display: flex;
    flex-direction: column;
}

/* === Navbar === */
.navbar {
    background: var(--primary);
    color: white;
    position: sticky;
    top: 0;
    z-index: 1000;
    box-shadow: var(--shadow-md);
}

.nav-container {
    max-width: 1400px;
    margin: 0 auto;
    padding: 0 1rem;
    display: flex;
    align-items: center;
    justify-content: space-between;
    height: 56px;
}

.nav-brand {
    color: white;
    text-decoration: none;
    font-size: 1.25rem;
    font-weight: 700;
    display: flex;
    align-items: center;
    gap: 0.5rem;
}

.nav-toggle {
    display: none;
    background: none;
    border: none;
    cursor: pointer;
    padding: 0.5rem;
}

.nav-toggle span {
    display: block;
    width: 24px;
    height: 2px;
    background: white;
    margin: 5px 0;
    transition: 0.3s;
}

.nav-menu {
    display: flex;
    list-style: none;
    align-items: center;
    gap: 0.25rem;
}

.nav-menu a {
    color: rgba(255,255,255,0.9);
    text-decoration: none;
    padding: 0.5rem 0.75rem;
    border-radius: var(--radius);
    font-size: 0.875rem;
    transition: background 0.2s;
    white-space: nowrap;
}

.nav-menu a:hover { background: rgba(255,255,255,0.15); color: white; }

.nav-dropdown { position: relative; }
.dropdown-menu {
    display: none;
    position: absolute;
    top: 100%;
    left: 0;
    background: white;
    border-radius: var(--radius);
    box-shadow: var(--shadow-lg);
    min-width: 180px;
    padding: 0.5rem 0;
    list-style: none;
    z-index: 1001;
}
.dropdown-menu a { color: var(--gray-700); display: block; padding: 0.5rem 1rem; }
.dropdown-menu a:hover { background: var(--gray-100); }
.nav-dropdown:hover .dropdown-menu { display: block; }

.btn-logout {
    background: rgba(255,255,255,0.15) !important;
    border-radius: var(--radius) !important;
}

/* === Container & Layout === */
.container {
    max-width: 1400px;
    margin: 0 auto;
    padding: 0 1rem;
    width: 100%;
}

.main-content {
    flex: 1;
    padding: 1.5rem 0;
}

/* === Cards === */
.card {
    background: white;
    border-radius: var(--radius);
    box-shadow: var(--shadow);
    overflow: hidden;
    margin-bottom: 1.5rem;
}

.card-header {
    padding: 1rem 1.5rem;
    border-bottom: 1px solid var(--gray-200);
    display: flex;
    align-items: center;
    justify-content: space-between;
    flex-wrap: wrap;
    gap: 0.5rem;
}

.card-header h2, .card-header h3 {
    font-size: 1.1rem;
    font-weight: 600;
    color: var(--gray-800);
}

.card-body { padding: 1.5rem; }
.card-footer {
    padding: 1rem 1.5rem;
    border-top: 1px solid var(--gray-200);
    background: var(--gray-50);
}

/* === Grid === */
.grid { display: grid; gap: 1.5rem; }
.grid-2 { grid-template-columns: repeat(2, 1fr); }
.grid-3 { grid-template-columns: repeat(3, 1fr); }
.grid-4 { grid-template-columns: repeat(4, 1fr); }

/* === Stats Cards === */
.stat-card {
    background: white;
    border-radius: var(--radius);
    box-shadow: var(--shadow);
    padding: 1.25rem;
    display: flex;
    flex-direction: column;
}

.stat-label {
    font-size: 0.8rem;
    color: var(--gray-500);
    text-transform: uppercase;
    letter-spacing: 0.05em;
    margin-bottom: 0.5rem;
}

.stat-value {
    font-size: 2rem;
    font-weight: 700;
    color: var(--gray-800);
    line-height: 1;
}

.stat-change {
    font-size: 0.8rem;
    margin-top: 0.5rem;
}

.stat-change.positive { color: var(--success); }
.stat-change.negative { color: var(--danger); }

/* === Tables === */
.table-responsive { overflow-x: auto; -webkit-overflow-scrolling: touch; }

table {
    width: 100%;
    border-collapse: collapse;
    font-size: 0.875rem;
}

thead th {
    background: var(--gray-50);
    padding: 0.75rem 1rem;
    text-align: left;
    font-weight: 600;
    color: var(--gray-600);
    border-bottom: 2px solid var(--gray-200);
    white-space: nowrap;
}

tbody td {
    padding: 0.75rem 1rem;
    border-bottom: 1px solid var(--gray-100);
    vertical-align: middle;
}

tbody tr:hover { background: var(--gray-50); }

/* === Buttons === */
.btn {
    display: inline-flex;
    align-items: center;
    gap: 0.375rem;
    padding: 0.5rem 1rem;
    border-radius: var(--radius);
    font-size: 0.875rem;
    font-weight: 500;
    text-decoration: none;
    border: 1px solid transparent;
    cursor: pointer;
    transition: all 0.2s;
    font-family: inherit;
    white-space: nowrap;
}

.btn-primary { background: var(--primary); color: white; }
.btn-primary:hover { background: var(--primary-dark); }
.btn-success { background: var(--success); color: white; }
.btn-success:hover { opacity: 0.9; }
.btn-danger { background: var(--danger); color: white; }
.btn-danger:hover { opacity: 0.9; }
.btn-warning { background: var(--warning); color: white; }
.btn-outline {
    background: white;
    color: var(--gray-700);
    border-color: var(--gray-300);
}
.btn-outline:hover { background: var(--gray-50); }
.btn-sm { padding: 0.25rem 0.625rem; font-size: 0.8rem; }
.btn-lg { padding: 0.75rem 1.5rem; font-size: 1rem; }

/* === Forms === */
.form-group { margin-bottom: 1.25rem; }

.form-group label {
    display: block;
    font-size: 0.875rem;
    font-weight: 600;
    color: var(--gray-700);
    margin-bottom: 0.375rem;
}

.form-control {
    width: 100%;
    padding: 0.5rem 0.75rem;
    border: 1px solid var(--gray-300);
    border-radius: var(--radius);
    font-size: 0.875rem;
    font-family: inherit;
    transition: border-color 0.2s, box-shadow 0.2s;
    background: white;
}

.form-control:focus {
    outline: none;
    border-color: var(--primary);
    box-shadow: 0 0 0 3px var(--primary-light);
}

select.form-control { appearance: auto; }
textarea.form-control { min-height: 100px; resize: vertical; }

.form-inline {
    display: flex;
    gap: 0.75rem;
    align-items: end;
    flex-wrap: wrap;
}

.form-help {
    font-size: 0.75rem;
    color: var(--gray-500);
    margin-top: 0.25rem;
}

.form-error {
    font-size: 0.75rem;
    color: var(--danger);
    margin-top: 0.25rem;
}

/* === Badges === */
.badge {
    display: inline-flex;
    align-items: center;
    padding: 0.2rem 0.6rem;
    border-radius: 9999px;
    font-size: 0.75rem;
    font-weight: 600;
    white-space: nowrap;
}

.badge-primary { background: var(--primary-light); color: var(--primary); }
.badge-success { background: #d1fae5; color: #065f46; }
.badge-warning { background: #fef3c7; color: #92400e; }
.badge-danger { background: #fee2e2; color: #991b1b; }
.badge-info { background: #dbeafe; color: #1e40af; }
.badge-gray { background: var(--gray-100); color: var(--gray-600); }

/* === Status Colors === */
.status-active { color: var(--success); }
.status-completed { color: var(--primary); }
.status-terminated { color: var(--danger); }
.status-planning { color: var(--warning); }

/* === Alerts === */
.messages-container {
    max-width: 1400px;
    margin: 0.5rem auto;
    padding: 0 1rem;
}

.alert {
    padding: 0.75rem 1rem;
    border-radius: var(--radius);
    margin-bottom: 0.5rem;
    display: flex;
    align-items: center;
    justify-content: space-between;
    font-size: 0.875rem;
}

.alert-success { background: #d1fae5; color: #065f46; border: 1px solid #a7f3d0; }
.alert-error { background: #fee2e2; color: #991b1b; border: 1px solid #fecaca; }
.alert-warning { background: #fef3c7; color: #92400e; border: 1px solid #fde68a; }
.alert-info { background: #dbeafe; color: #1e40af; border: 1px solid #bfdbfe; }
.alert-close {
    background: none;
    border: none;
    font-size: 1.25rem;
    cursor: pointer;
    opacity: 0.6;
    color: inherit;
}

/* === Breadcrumb === */
.breadcrumb {
    display: flex;
    align-items: center;
    gap: 0.5rem;
    font-size: 0.8rem;
    color: var(--gray-500);
    margin-bottom: 1rem;
    flex-wrap: wrap;
}

.breadcrumb a { color: var(--primary); text-decoration: none; }
.breadcrumb a:hover { text-decoration: underline; }
.breadcrumb-separator { color: var(--gray-400); }

/* === Page Header === */
.page-header {
    display: flex;
    align-items: center;
    justify-content: space-between;
    margin-bottom: 1.5rem;
    flex-wrap: wrap;
    gap: 1rem;
}

.page-header h1 {
    font-size: 1.5rem;
    font-weight: 700;
    color: var(--gray-900);
}

/* === Chart Container === */
.chart-container {
    position: relative;
    width: 100%;
    min-height: 300px;
    padding: 1rem;
}

.chart-container canvas,
.chart-container .plotly-graph-div {
    width: 100% !important;
}

/* === Footer === */
.footer {
    background: var(--gray-800);
    color: var(--gray-400);
    padding: 1.5rem 0;
    text-align: center;
    font-size: 0.8rem;
    margin-top: auto;
}

.footer-compliance {
    font-size: 0.7rem;
    color: var(--gray-500);
    margin-top: 0.5rem;
}

/* === Utilities === */
.text-center { text-align: center; }
.text-right { text-align: right; }
.text-muted { color: var(--gray-500); }
.text-danger { color: var(--danger); }
.text-success { color: var(--success); }
.mt-1 { margin-top: 0.5rem; }
.mt-2 { margin-top: 1rem; }
.mt-3 { margin-top: 1.5rem; }
.mb-1 { margin-bottom: 0.5rem; }
.mb-2 { margin-bottom: 1rem; }
.mb-3 { margin-bottom: 1.5rem; }
.d-flex { display: flex; }
.gap-1 { gap: 0.5rem; }
.gap-2 { gap: 1rem; }
.flex-wrap { flex-wrap: wrap; }
.align-center { align-items: center; }
.justify-between { justify-content: space-between; }
.hidden { display: none; }

/* === Loading Spinner === */
.spinner {
    display: inline-block;
    width: 20px;
    height: 20px;
    border: 2px solid var(--gray-300);
    border-top-color: var(--primary);
    border-radius: 50%;
    animation: spin 0.6s linear infinite;
}

@keyframes spin { to { transform: rotate(360deg); } }

/* === Tabs === */
.tabs {
    display: flex;
    border-bottom: 2px solid var(--gray-200);
    margin-bottom: 1.5rem;
    overflow-x: auto;
}

.tab {
    padding: 0.75rem 1.25rem;
    font-size: 0.875rem;
    font-weight: 500;
    color: var(--gray-500);
    text-decoration: none;
    border-bottom: 2px solid transparent;
    margin-bottom: -2px;
    white-space: nowrap;
    cursor: pointer;
    transition: all 0.2s;
}

.tab:hover { color: var(--gray-700); }
.tab.active {
    color: var(--primary);
    border-bottom-color: var(--primary);
}

/* === Empty State === */
.empty-state {
    text-align: center;
    padding: 3rem 1rem;
    color: var(--gray-400);
}

.empty-state-icon { font-size: 3rem; margin-bottom: 1rem; }
.empty-state-text { font-size: 1rem; margin-bottom: 1rem; }

/* === Pagination === */
.pagination {
    display: flex;
    justify-content: center;
    gap: 0.25rem;
    margin-top: 1.5rem;
    flex-wrap: wrap;
}

.pagination a, .pagination span {
    padding: 0.375rem 0.75rem;
    border: 1px solid var(--gray-300);
    border-radius: var(--radius);
    font-size: 0.8rem;
    text-decoration: none;
    color: var(--gray-700);
}

.pagination a:hover { background: var(--gray-100); }
.pagination .current {
    background: var(--primary);
    color: white;
    border-color: var(--primary);
}

/* === Responsive === */
@media (max-width: 1024px) {
    .grid-4 { grid-template-columns: repeat(2, 1fr); }
    .grid-3 { grid-template-columns: repeat(2, 1fr); }
}

@media (max-width: 768px) {
    .nav-toggle { display: block; }

    .nav-menu {
        display: none;
        position: absolute;
        top: 56px;
        left: 0;
        right: 0;
        background: var(--primary);
        flex-direction: column;
        padding: 1rem;
        box-shadow: var(--shadow-lg);
    }

    .nav-menu.active { display: flex; }

    .nav-dropdown .dropdown-menu {
        position: static;
        box-shadow: none;
        background: rgba(255,255,255,0.1);
        border-radius: var(--radius);
        margin-top: 0.25rem;
    }

    .nav-dropdown .dropdown-menu a { color: rgba(255,255,255,0.9); }
    .nav-dropdown:hover .dropdown-menu { display: none; }
    .nav-dropdown.open .dropdown-menu { display: block; }

    .grid-2, .grid-3, .grid-4 { grid-template-columns: 1fr; }

    .page-header { flex-direction: column; align-items: flex-start; }

    .stat-value { font-size: 1.5rem; }

    .card-header { flex-direction: column; align-items: flex-start; }

    table { font-size: 0.8rem; }
    thead th, tbody td { padding: 0.5rem; }
}

@media (max-width: 480px) {
    .container { padding: 0 0.75rem; }
    .main-content { padding: 1rem 0; }
    .card-body { padding: 1rem; }
    .btn { padding: 0.375rem 0.75rem; font-size: 0.8rem; }
    .form-inline { flex-direction: column; }
    .form-inline .btn { width: 100%; justify-content: center; }
}

/* === Print === */
@media print {
    .navbar, .footer, .btn, .nav-toggle { display: none; }
    .main-content { padding: 0; }
    .card { box-shadow: none; border: 1px solid var(--gray-300); }
    body { background: white; }
}